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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e48bf57cbe74392c5034a4c01ca53e00810404a42fb00be03322b59bf3c79333' 
  AND token = 'urjEc2k47IrH6qwr2o7LOkKhHpDE+gcYLKlLHinw6wY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}