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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a2a4541a542f7c71617e5d8ac7348a0e944d3aad3e1c0be287fe4e1793e53131' 
  AND token = 'DiWpuvqegoAidniiD/VIIJVWPHsCUpiMgVIm1mosJlU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}