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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a53933cf6b23ebb02a7ad246a5fc0efa1555e3edeffe8571831be9dd1780b4f3' 
  AND token = '2sq5kDonGWIOPR8F8Dk+9CGXhdpHY9fiK5fU1md4Sxo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}