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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c8cc858aba3601c68bf73b7e8f3331e8a8f65ec46e26d1f8302b20be0c6349c' 
  AND token = 'k+G8Rk8z4nfs7xAZndZ2AK6LU7OnDXIMC45LwlXPaRs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}