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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2167fa462915ba2c88428a58616c7b7e8bda5a469cf8adce84f36d67c9f74325' 
  AND token = 'L2W8vyw6tpxNJcJdLa10RbhGB2PxPTCUCYOfe1D57Ts=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}