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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8380fb086fc25272698be2ecf985cb3eb355b0f3b1ccdaffbc27dbc0125a44b0' 
  AND token = 'txmPzjYY+OrAhyf2GIFUHOLJol6FvTVfHCTdGdo0eDI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}