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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4da70e0dd3a5a3c56dec5a40d2d441a0a204b10aa3e0a560caaa5db07d26df92' 
  AND token = 'VpZ9dDuG+maCPYiqUHMI9MzfkYaCHCuU26lKfHbmojQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}