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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78ddfcb2b815586ac90a1242b4354190f75b74bb4d01526738a305a4feea96bb' 
  AND token = 'dVYLSJydrx7QnKe3KYvorFTW6TPHxlTlx7kKm9Hw0a4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}