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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fc15ec4b390a830a664ddb490b20bc5b00223052b3ca047349a3fd8fa8393675' 
  AND token = 'j57D0LbEJW+7+wc0lGx30vgFGSDm2XTd4+A3JlFWI6s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}