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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f6e6df8e0b30d1524442374d427d42a5ec0f9e298a0b50c5caa04e665109490' 
  AND token = 'CqgKVF8UnbtujohV1TIUnVD1cU3qGnYEqfdlAsrb3j4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}