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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3fc0201ed63b92f5dee667a9d9848179efecf0246a618eb7ff9a09a249f2a46f' 
  AND token = 'Up/nApYs93DMYaL+KPilLnHYpmKL2HfXr/FPHHhIGog=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}