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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21712813854e7eaed204e936c2ea35c12e211d1cac4541ad71bad2696dec779f' 
  AND token = 'rUt+UsOWWNbKlX45+I2klVVh1QbMX3vBMtjE2ihSk6Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}