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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7816f3b87d46b188c5bdfd02892c18514e4993c2e99b58288ae8b6606e2489c8' 
  AND token = 'A3zoW4qylmaog41t3InjGOxES8profKr6WAbj4+GeBg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}