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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22ade80fe1b7dce6ac54ac8f9aa9ad2bd23d5dcf1adb82a26227f2e9a5b2d39f' 
  AND token = 'NRtAYSQOh4cmoAB9kBQf+Y4mt6PHnCs6LnwjaCgRukg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}