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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '777a952ab20f2f0a32249f7ea5aa192276b55d0d9aae10b2b05f16b9c62602dd' 
  AND token = 'NAv/bL+CI5gPvIMsYTc0A/32MTzRHrKS/wxkmfSGTMw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}