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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3aef5aa608752e48aebced284ad153354a6dcb87ea24fab7fc4c3763cb978b15' 
  AND token = '4qki7ynfAJBjtSp5rJ79dLog5PPTUCPdW7FnjVRgiWs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}