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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c78219d12435e94aaea109cb1a49c81e649aaf67ff3395f3ebec58fec382b261' 
  AND token = 'QwqlNkMpYuxOA6CagZmDUA6z6NZyDFm9aaz1rQkcvrQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}