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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0b46e39c253f6559b449a606e282c0c41155d486e1e793559488019d7082c0ce' 
  AND token = 'TmeRqShPUD0nzmM57KN9yV3sW9VKvCmg9atYWfwSNrs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}