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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'da5e6e2b331d65ecec0a505bfcc670cbedcbc33ca6c2929bf1c081bdd28a5c27' 
  AND token = 'J8uNhrSDO1FC4gXiFi3BMgW1UEsdegbHnvOjTYmzt5s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}