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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '878f8b194a767407a02f70d9af331e94f3d1727cb333c48652f212454618780d' 
  AND token = 'NotrqJJ1vsq5pvTtzpr3J0/voWAYUD2ZEBwk36+UfU0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}