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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72c26229df165bf64ce7039ad3068e7ddb8751f4733210931706fed38b6da289' 
  AND token = '2tWd0EK3XW/aKruvoDR6PzdMah+TEkPTvUTADtLPcKs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}