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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ec25a20749514fe037f4141a56ac5c6cdfe38e1420e462b4d8e68ed11c20b369' 
  AND token = 'oZ8CyTH7+iTBdcnev/FKQlbRGPwjMlNKBKb35nrHlvc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}