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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7d28b599f316a342f3fdde8837262456f036f271c5217cb12dc05da604e45eb4' 
  AND token = 'Nz64ESA81tXN+JjtbZ5+/6aZqBgx7r9HCtTdvFnZr2I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}