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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b65a448d13ec86f9f80a398dc9a0e3d1017576d6e4dc96da51482bad240ebf95' 
  AND token = 'V6BUrM+V9xcTNnpjfgaV5d/1vR3OaZnkRyTQP8csAFE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00044

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}