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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '004c33e718779795194ee230d7629dfc4e0b4abfda21de5fefd693c4896b1377' 
  AND token = '9GyUEcmRAI3w+UdOlYvk3Y4Mr8+3sMAOmu3Ux9EK3BM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}