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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '27e50b0653e9d62b689b02d27aeba23848e2ef1247d583952b65f9e8ecd0e46c' 
  AND token = 'JpzHQzp8mNecRXz+WIeFIerZnWzINaEtIo9cQ8ZNEg4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}