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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c339053b95ecb7022edb16692c420e0f343e1fa878b4bb008cdd86aa11cb0289' 
  AND token = 'tJ9TNAfkWSdc54TkBtJyO4DwzD+m8areH4wJxgVwHRg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}