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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '181542e247a157b0efaba4201ab309c25285691481af96160c93d3d28321e2f8' 
  AND token = '8XOFSbiMHBikLtEBmdAl10aXlj+bMjMFClya7RSF/q4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}