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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cf73d21dc3bed5f7edd17e905ac69fc04417a7a0188d712e84b9724b25cccb67' 
  AND token = '+TY2GEOp4VGTjyrDcsPPyBgdlWLxKy1mBnNqDB7mYFE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}