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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b4b34e202ac084d4e51c693fbd55d3510c739a39956433e868a71dcff4a46d6c' 
  AND token = 'cE66HRjrqO/QylApluBjAEf53pRirWCKm2UsIKLH5Fg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}