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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49d6183026908af44066289e371c1fe06c0487ace2f4d700b848c24df16eee14' 
  AND token = 'yfkuY4zBXeFkpKKM7TcFhtwMfgBoLZMoqC6XpYPGwJI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}