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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4ddd045e2777f997b1563446e69302e93952f9c7c65e502d44acb103effcb3a2' 
  AND token = 'eDWcN/W23lVCrPc49M+1/zxvHG8rNrXVlf8JMr0HIxg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}