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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5387d3e541d8dd898f4726d2acd88253f46b7a26d7e464f5b48db3f0d09657fc' 
  AND token = '+EEY8vweLONToY852Bdkl9wXEyHdLHZgw81LVBpsk1k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}