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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '021160c08c24a5aa01fa6f0386b54474335ff2d0c87c2aa1322ecb12885807a6' 
  AND token = 'RezMuKPl/qy0Ilxs+uGBtvWXcAmMCFCvdpR1BpfU/DY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}