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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '88e6eb5c58502836e31e6a395bb47ac8eb39629a6c1b7a2b14a22f3f458513a9' 
  AND token = 'jEGfmGoO/e+fGIRfTKTvDZt9RjYDGaNt6ogUHA6NwaQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}