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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e09225779535ba2c1ae031890dbffe2191f45075c8d2e2a40418970e282c273' 
  AND token = 'vMVD4x6cSqNEdiKwqpnNgB3vit2bEJ87W889+P5byTA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}