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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cfc104d60c4d27a0f17202df2a2648058ee487c083623320730db12d4fab2f28' 
  AND token = 'AS0ZGFjkOA+BhUaUsbBOUjJZTKsFUye2PJphnzC8R2E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}