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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '216af1603d758462ecf8fa01211b72a8f148b07b708ba11a027ad87c166dbd6d' 
  AND token = 'f3V3hEO4/58AtJpjxm8AvAZPiatE9qk3wKNhgkMb1Ss=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}