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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'bce66f53c1d7334e80b211d36b3fd8e8af1a92d1e65fa1736876428ee8486611' 
  AND token = 'Z5a/8+Of/SvDy++zelGgm2sMeMTmzE4LGgZp68e0QL0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}