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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43d8f70417d7bd3fa93f820ef9b63b84e367f8de00312c84e9af0c58069887dc' 
  AND token = '/TPzuZ53ytJxp8EOBxPPPq963mePKNHKMBu8iOoKj7g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}