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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ae5fc5f91127728f3f532731a3db78863f00f9956b37a23e4257f57a353835d5' 
  AND token = 'kwCMD2VdeYHI+6NUXSq3svodT3fSyPgL0rCmPWyJ6xc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}