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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'afd3a092299f1e075169f63f9a1cb75e6d9d13db43d11a462bd9490a379a3bca' 
  AND token = 'KnaYg9XmGhKUvWY8/LZCORu1pK3JLr2vVbCdhK0Sy9o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}