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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1de519d2801844a025d69e9912b8779184d50b75efaf68dd959d2a32580de8e2' 
  AND token = 'm6E6pec5bDwjUqVe8fPLqxx7or/XeB1P+WmYKycMSyg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}