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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4dc74691f2a69cf8a9fdbf331f46a8580f0baadd3a0f520a70a033288dd4d270' 
  AND token = 'N/ZQLdgg6bSlImz+fq1BKNQ0fvxKeAOMLPMaZJDBlfE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}