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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80bb975e33419f73545ce1d69b70a54c2c09014ee3830278ba036772ad84706d' 
  AND token = 'uB28ReMvo5v2cJQU29UEDbLS58UHNxt0XCrB7wfLhdw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}