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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e1f56adc44b505671c026a90e8a4b0fdfff05ab2ba32ba0e9b0f052248c2547' 
  AND token = 'ntJ7tD1mgo0/2wx1CmqAN0K9s1n1gPdsM8VHqh0PE8g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}