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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ef160a845cc794d329fcfc79ca15bd7ee9b6f81aa9520d3f9eb780805947213c' 
  AND token = 'A3Q6UuEqRk+2h+U1crIqc+g9MRrPylqhcqMVyjcM1Lk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}