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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '07498ae15e2f6cf2c1e5cc52c22280f3f15e380313040099f5a32e1007317a63' 
  AND token = 'xp3SlgMexMtibRzR1AaDiuxc+M4k2XSVWQHRboTW5Cw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}